Otogelin-like protein (OTOGL)

Otogelin-like protein (OTOGL) is a large secreted glycoprotein expressed predominantly in the inner ear, especially during embryonic and early postnatal development[2]. It contains several structural domains including von Willebrand factor (vWF), cysteine-rich (C8), trypsin inhibitor-like (TIL), and a C-terminal cysteine-knot (CTCK) domain[1][2]. OTOGL is localized to the acellular membranes of the cochlea (including the tectorial membrane) and contributes to the structural integrity of hair bundles by forming horizontal top connectors and tectorial membrane-attachment crowns through interaction with proteins like otogelin and stereocilin[1]. Mutations in OTOGL can cause autosomal recessive, non-syndromic sensorineural hearing loss, known in genetic nomenclature as DFNB84B[2]. The protein’s function is structural and mechanical, ensuring proper coupling and mechanotransduction in the cochlear hair cells, rather than signal transduction or enzymatic activity. No drugs or research tools are known to specifically target OTOGL, nor is it used as a biomarker in therapeutic contexts.

Other names

OTOGLC12orf64FLJ90579DFNB84BOtogelin-like protein

Not applicable; no known drugs target otogelin-like