OTU deubiquitinase 1 (OTUD1)

OTU deubiquitinase 1 (OTUD1) is a member of the OTU (ovarian tumor) family of cysteine proteases classified as a deubiquitinating enzyme (DUB). It specifically hydrolyzes K63-linked polyubiquitin chains, thereby regulating various signaling pathways including canonical NF-κB activation, interferon antiviral responses, apoptosis, necroptosis, and antioxidant mechanisms via KEAP1 binding. OTUD1's biological roles extend to ribosome quality control by deubiquitinating ribosomal protein RPS10/eS10, influencing mRNA stability and translation in cells, and enhancing iron transport through stabilization of IREB2. Aberrant OTUD1 function or expression is linked to cancer aggressiveness, inflammatory conditions, and neurodegenerative disease. While no drugs currently target OTUD1, it represents a promising therapeutic target due to its central role in controlling inflammation, cell death, and proteostasis

Other names

OTU domain-containing protein 1OTUD1DUBA7OTDC1OTU domain containing 1DUBA-7

Drugs (if developed) would likely inhibit or modulate OTUD1's deubiquitinating activity, affecting K63-linked ubiquitin chain hydrolysis, NF-κB signaling, and downstream apoptotic or inflammatory processes