OTU domain-containing protein 6A (OTUD6A)

OTU domain-containing protein 6A (OTUD6A) is a deubiquitinating enzyme, part of the OTU (ovarian tumor) subfamily of cysteine proteases, characterized by a conserved cysteine-histidine-aspartate catalytic triad[2][5]. OTUD6A specifically hydrolyzes lysine-27, -29, -33, and -11-linked polyubiquitin chains and plays a key role in regulating the stability of proteins involved in oncogenesis, apoptosis, and cell cycle progression by removing ubiquitin chains that tag proteins for proteasomal or lysosomal degradation[5][1]. It stabilizes multiple oncogenic proteins, including nucleolin, Drp1, Aurora kinase-A, and c-Myc, thereby promoting cell proliferation and tumorigenesis in various cancers including breast, prostate, and colorectal cancer[1][3]. OTUD6A also modulates mitochondrial dynamics and is implicated in the regulation of TEAD-driven transcriptional programs[4]. Elevated expression of OTUD6A is associated with poor patient prognosis in breast and other cancers, suggesting its emerging relevance as a potential therapeutic target and prognostic biomarker[1]. No specific approved drugs or drug candidates are currently known to target OTUD6A directly.

Other names

OTUD6ADUBA2FLJ25831HSHIN6DUBA-2HIN-6 proteaseOTU deubiquitinase 6A

Inhibition of deubiquitinase activity; Disruption of substrate recognition or catalytic triad; Inhibition of OTUD6A-mediated stabilization of oncogenic proteins (in principle, but no specific drugs identified)