OTU domain-containing protein 6B (OTUD6B)

OTU domain-containing protein 6B is a cysteine-type deubiquitinase, part of the OTU protease family, using a conserved catalytic triad of cysteine, histidine, and aspartate. It removes ubiquitin from protein substrates, regulating their degradation, participating in cell cycle control (in B cells), protein synthesis, growth, and proteasome function. Loss-of-function mutations in humans are linked to developmental disorders with intellectual disability, seizures, and distinct limb anomalies[1][2][3][4].

Other names

OTU domain-containing protein 6BDUBA5OTUD6BOTU6B

Drugs hypothetically targeting OTUD6B would likely act as inhibitors or modulators of its deubiquitinating activity, affecting protein degradation and cell cycle pathways (speculative, as no approved drugs are known[2][4])