Outer capsid glycoprotein VP7 (Rotavirus A serotype G4) (VP7)

Outer capsid glycoprotein VP7 is a major structural protein of Rotavirus A, specifically the G4 serotype, which is a leading cause of severe dehydrating gastroenteritis in infants and young children globally (Source: WHO, 2021). VP7 forms the smooth outer surface of the triple-layered rotavirus particle and is essential for the virus's ability to infect host cells by mediating attachment and subsequent uncoating in a calcium-dependent manner (Source: UniProt, 2023). As one of the two primary neutralization antigens, VP7 G4 is a critical component in the design of live-attenuated vaccines like RotaTeq, which includes a human-bovine reassortant strain expressing the G4 serotype (Source: FDA, 2020). The protein's antigenic properties are defined by its G-type, and immunity to VP7 is a key correlate of protection against subsequent infection (Source: PubMed, 2022). Monitoring the prevalence of the G4 serotype is vital for public health, as shifts in dominant serotypes can impact the effectiveness of regional vaccination programs (Source: CDC, 2023).

Other names

Glycoprotein VP7G-proteinVP7 serotype G4Outer capsid protein VP7Major neutralization antigen VP7

Induction of neutralizing antibodies that block viral attachment and uncoating