Outer dynein arm docking complex subunit 2 (ODAD2)

Outer dynein arm docking complex subunit 2 (ODAD2) is a cytoplasmic protein that forms part of the outer dynein arm docking complex (ODA-DC), which is essential for the proper attachment and spatial arrangement of outer dynein arms on the axonemal doublet microtubules of cilia and flagella[2][3][7]. ODAD2 contains multiple armadillo repeat motifs and one HEAT repeat, indicating a role in protein–protein interactions and complex assembly[2]. It localizes specifically to ciliary axonemes and the base of respiratory cilia[2]. Functionally, ODAD2 helps mediate the binding and periodic arrangement of the dynein arms, which generate the force required for ciliary and flagellar motility. Loss-of-function mutations in ODAD2 cause defects in ciliary beating, contributing to conditions such as primary ciliary dyskinesia, which is characterized by chronic respiratory disease and defects in left-right body asymmetry due to impaired ciliary motility[2][8]. There are no known drugs directly targeting ODAD2, nor is it considered a therapeutic target, but its mutation status is relevant as a biomarker in the clinical genetics of ciliary disorders[2][8].

Other names

ARMC4FLJ10817FLJ10376DKFZP434P1735CILD23guduArmadillo repeat-containing protein 4testis tissue sperm-binding protein Li 74n