Target intelligence / Profile preview

Outer Membrane Porin Protein PorA P1.4 (PorA P1.4)

Target: PorA P1.4
Molecular classification: Porin, Outer Membrane Protein

Overview

PorA subtype P1.4 is a structurally distinct variant of an essential Neisserial porin that serves both physiological roles as a channel protein and critical pathogenic functions through interaction with host immunity—including being one of the main targets for protective vaccine-induced antibody responses against serogroup B N.meningitidis infections.

Other names: PorA subtype P1.4P1.4 PorAMeningococcal PorA P1.4

Mechanism of action

Antibody-mediated complement activation and bacterial killing

Biological functions

Passive transportHost cell adhesionImmune evasionComplement activationInduction of pro-inflammatory cytokines

Disease associations

InfectionMeningococcal disease

Safety considerations

Potential for phase variation leading to immune escapeStrain-specific efficacy of vaccines

Interacting drugs

Vaccines (OMV-based)

1 more in the full profile.

Biomarkers

Expression level of PorA P1.4 in Neisseria meningitidis strains

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