Outer Membrane Protein F (OprF)

Outer Membrane Protein F (OprF) is a major porin and structural protein found in the outer membrane of the Gram-negative bacterium *Pseudomonas aeruginosa*. It plays critical roles in maintaining cell integrity, permeability, and interaction with the environment and host during infection. It acts as a non-specific diffusion channel, allowing passive transport of small hydrophilic molecules, and is essential for maintaining cell shape and outer membrane morphology. OprF is also involved in biofilm formation, quorum sensing, adhesion to host tissues, and is a potential vaccine candidate.

Modulation of porin function or expression to enhance antibiotic susceptibility or disrupt biofilm formation