Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Outer Membrane Protein I (OprI)
- Target
- OprI
- Molecular classification
- Lipoprotein, Outer membrane protein
01
Overview
Outer membrane protein I (OprI) is a small, highly conserved lipoprotein found in the outer membrane of *Pseudomonas aeruginosa*. It plays a significant role in the bacterium’s interaction with host defense mechanisms, serving as a receptor for cationic antimicrobial peptides, and contributes to cell envelope stability. It is considered a potential vaccine candidate.
02
Mechanism of action
OprI serves as a receptor for cationic antimicrobial peptides, leading to bacterial cell disruption or modulation of the immune response.
03
Biological functions
Antimicrobial peptide receptorCell envelope integrityImmune evasion
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Potential for off-target effects in vaccine developmentDevelopment of resistance through OprI modification or downregulation
06
Interacting drugs
Cationic antimicrobial peptides (AMPs)
2 more in the full profile.
Beyond the preview
Go deeper on Outer Membrane Protein I (OprI).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Outer Membrane Protein I (OprI).