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Target intelligence / Profile preview
Outer Membrane Protein of Neisseria meningitidis Group B (OMP)
- Target
- OMP
- Molecular classification
- Outer Membrane Protein, Porin, Adhesin, Enzyme (e.g., M23 metallopeptidase), Lipoprotein, Antigen
01
Overview
The outer membrane proteins (OMPs) of *Neisseria meningitidis* group B are key components of the bacterial cell envelope. They are involved in nutrient transport, adhesion to host cells, and immune evasion. Specific OMPs like PorA and NadA are major vaccine targets, eliciting protective antibody responses. The OMPs also contribute to serotype specificity. Some OMPs, such as NMB0315, exhibit enzymatic activity. Variability in OMP expression and serotype distributions pose challenges for vaccine development and effectiveness.
- Other names
- N. meningitidis Group B OMPsPorAPorBOpcANspANadANHBANMB0315
02
Mechanism of action
N/A (Vaccines induce antibody production against OMPs)
03
Biological functions
Nutrient transportAdhesion to host cellsSerotype determinationImmune evasionEnzymatic activity (e.g., peptidoglycan cleavage)Structural component of outer membraneVaccine antigen
04
Disease associations
InfectionMeningitisSepticemia
05
Safety considerations
Potential for serotype replacement after widespread vaccinationVariability in OMP expression between strainsLimited cross-protection between different OMP variants
06
Biomarkers
Antibody titers against specific OMPs (e.g., PorA, NadA)Serotype of infecting N. meningitidis strain
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