Target intelligence / Profile preview

Ovalbumin (OVA)

Target
OVA
Molecular classification
Serpin superfamily (non-inhibitory member)[3][4][6][7], Phosphoglycoprotein[1][7][8], Storage protein[3][6]
01

Overview

Ovalbumin is the major protein in chicken egg white, accounting for about 55% of its protein content[3][7]. It displays homology to the serpin superfamily but, unlike inhibitory serpins, it does not inhibit proteases and instead likely serves a storage or structural role[1][3][7]. Ovalbumin has a molecular mass of ~45 kDa, is glycosylated and phosphorylated, and consists of 385–386 amino acids[3][7]. Its structure has been widely used in studies of protein folding, aggregation, and allergenicity. Ovalbumin is a standard immunological reagent, as its strong antigenicity makes it a useful model protein for allergy research[3][7]. It is also important in food science due to its contribution to the gelation, foaming, and emulsification properties of egg whites[7].

Other names
OVAegg albuminegg white protein
02

Biological functions

Presumed nutrient storage[3][7]Model allergen for immunology studies[3]Protein structure, gelation, foaming, and emulsification in food science[7]
03

Disease associations

Other (allergen; used to model IgE-mediated allergic reactions such as egg allergy)[3]
04

Safety considerations

Can cause allergic reactions (egg allergy/allergen)[3]When used in research involving immunization, endotoxin levels must be controlled
05

Biomarkers

Used experimentally as a model allergen for airway hyper-responsiveness studies in allergy and immunology[3]

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