Ovo-like zinc finger transcription factor 2 (OVOL2)

Ovo-like zinc finger transcription factor 2 (OVOL2) is a DNA-binding transcription factor belonging to the evolutionarily conserved ovo-like protein family, characterized by a conserved set of C2H2-type zinc finger domains[1][2][4]. It is essential in maintaining epithelial cell lineage identity, mainly by suppressing epithelial-to-mesenchymal transition (EMT)[1][3][4]. OVOL2 also regulates neuronal differentiation, adipogenesis, and the development of primordial germ cells[1][3][4]. As a transcriptional repressor, it inhibits the expression of key EMT inducers (such as ZEB1) and other factors promoting cell proliferation and differentiation[1][3]. Loss of OVOL2 function in mice is embryonic lethal and causes defects in neuroectoderm, vascular, and cardiac development[1]. In humans, loss-of-function mutations in OVOL2 are associated with posterior polymorphous corneal dystrophy, and emerging data suggest tumor suppressor roles via regulation of EMT and cell cycle-related genes[1][3][5]. OVOL2 does not currently have known approved or clinical-stage drugs targeting it directly, but it is considered a therapeutic target, especially in oncology and regenerative medicine applications where modulation of EMT and epithelial lineage specification are of interest[3].

Other names

Ovo like zinc finger 2OVOL2Zinc finger protein 339CHED1ZNF339