Ovochymase 1 (OVCH1)

Ovochymase 1 (OVCH1) is a protein-coding gene in humans that encodes a serine-type endopeptidase predicted to localize to the extracellular region and act in proteolysis[3][1]. The protein is characterized by CUB domains and features typical of the peptidase S1A (trypsin/chymotrypsin) superfamily[1]. While there is no current evidence of drug targeting or approved ligands, OVCH1 is considered to have therapeutic potential due to its unique structural and biochemical properties and involvement in core cellular processes[2]. Diseases associated with OVCH1 include hereditary spherocytosis (type 5) and diversion colitis[3]. Additionally, its antisense RNA (OVCH1-AS1) is implicated in vascular aging and frailty biomarkers, suggesting a possible regulatory role in endothelial and smooth muscle cellular function in the context of aging and senescence[4]. OVCH1’s precise physiological substrates and biological pathways are not fully delineated, but it represents a member of the extracellular serine protease family with prospective roles in important pathophysiological contexts. Supporting details: OVCH1’s UniProt accession: Q7RTY7[2][3] Gene symbol: OVCH1 (HGNC:23080; NCBI:341350)[3][1] Structural features include CUB domain, peptidase S1A family domains[1] Detected associations with extracellular localization and suggested roles in proteolysis and metal ion binding[3][1] No validated drug interactions or mechanisms of action currently identified in accessible databases Antisense RNA, OVCH1-AS1, differentially expressed with aging and frailty states, noted as biomarker[4]

Other names

Ovochymase-1OVCH1OVCHovochymase-1OVCH1_HUMAN