OX-2 membrane glycoprotein (CD200)

CD200 is a broadly expressed cell surface glycoprotein with two immunoglobulin-like domains, functioning primarily to suppress myeloid cell activity via interaction with the CD200 receptor (CD200R), which is highly expressed on macrophages and other myeloid cells. This ligand-receptor axis is a key checkpoint in both innate and adaptive immunity, regulating inflammatory responses and maintaining self-tolerance. Increased or aberrant expression of CD200 is linked to immune evasion in cancers, while viral orthologs of CD200 are used by pathogens to reduce host defense. Soluble forms and splice variants of CD200 add to its complexity in clinical contexts. CD200 is a validated immunological target in oncology, neuroinflammation, and infectious disease research, recognized for its role in immune checkpoint regulation.

Other names

OX-2 membrane glycoproteinCD200MOX1MOX2My033MRCOX-2CD200 antigenantigen identified by monoclonal antibody MRC OX-2

For experimental anti-CD200 agents and antibodies: Blockade of CD200-CD200R interaction to restore immune activation in cancer or minimize immune suppression. CD200R engagement by CD200 leads to tyrosine phosphorylation and recruitment of DOK1/DOK2 adaptors, resulting in downstream inhibition of MAPK/ERK pathway, reduced proinflammatory cytokine production, suppressed immune cell activation, and prevention of mast cell degranulation.