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Tumor necrosis factor ligand superfamily member 4 (TNFSF4)

Target: TNFSF4
Molecular classification: Cytokine, TNF ligand family member

Overview

Tumor necrosis factor ligand superfamily member 4 (TNFSF4), also known as OX40 ligand (OX40L), CD252, TXGP1, gp34, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It plays a critical role in immune system regulation by acting as a co-stimulatory molecule for T cell activation and survival.

Other names: OX40 LigandOX40LCD252TXGP1gp34

Mechanism of action

OX40L acts as a co-stimulatory molecule, binding to OX40 and activating downstream signaling pathways that promote T-cell activation, proliferation, and survival.

Biological functions

Co-stimulation of T-cell proliferationT-cell cytokine productionT-cell survivalT-cell memory formationTh2 polarizationImmune response

Disease associations

Autoimmune diseasesInflammationCancer

Safety considerations

Potential for immune-related adverse events in therapeutic targeting.

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