Target intelligence / Profile preview

Oxalate

Molecular classification: Small molecule, Dicarboxylic acid dianion, Metabolite

Overview

Oxalate (ethanedioate) is a dicarboxylic acid dianion found in many plants and produced endogenously as a metabolic end-product in humans. While it plays roles in calcium homeostasis and detoxification in plants, it acts as an antinutrient in humans by binding to minerals like calcium, reducing their bioavailability. High levels of oxalate can lead to hyperoxaluria and increase the risk of kidney stone formation.

Other names: EthanedioateOxalic acid dianion

Biological functions

Mineral chelationCalcium homeostasis (in plants)pH regulation (in plants)Photosynthesis (in plants)Detoxification of heavy metals (in plants)Antinutrient (in humans)

Disease associations

Kidney stonesHyperoxaluriaProgressive kidney disease

Safety considerations

Kidney stone formationReduced mineral bioavailabilitySystemic toxicity in cases of renal dysfunction or genetic metabolic disordersSkin rashesPainful urination/bowel movements

Biomarkers

Urine oxalate levelsSerum oxalate levels

Beyond the preview

Go deeper on Oxalate.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Oxalate.

Explore the full profile