Target intelligence / Profile preview

Oxalate decarboxylase (OxDC)

Target: OxDC
Molecular classification: Enzyme, Lyase, Bicupin superfamily

Overview

Oxalate decarboxylase (EC 4.1.1.2) is an enzyme that catalyzes the conversion of oxalate into formate and carbon dioxide. It is a homohexameric enzyme belonging to the bicupin superfamily and requires manganese ions and dioxygen for its activity. It plays a role in glyoxylate and dicarboxylate metabolism and is involved in the response to acid pH stress in some bacteria. Engineered forms are being explored for hyperoxaluria treatment.

Other names: Oxalate carboxy-lyase

Mechanism of action

Catalyzes the conversion of oxalate to formate and carbon dioxide.

Biological functions

Glyoxylate and dicarboxylate metabolismResponse to acid pH stressOxalate degradation

Disease associations

HyperoxaluriaKidney stones

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