Oxalate ion

Oxalate ion is a small, planar dianion with the formula C₂O₄²⁻, produced by the deprotonation of oxalic acid. It is found as a normal metabolite in plants and animals and acts as a bidentate ligand in coordination chemistry. Oxalate is not itself a therapeutic target but can play a secondary role in human health, particularly in relation to kidney stone formation (calcium oxalate stones) and rare metabolic disorders such as primary hyperoxaluria. Free oxalate is typically measured in urine or plasma as a biomarker of stone risk or metabolic disturbance rather than as a molecular target for drugs or biologics. Because "Free oxalate" is not a canonical molecular target (such as a receptor, enzyme, ion channel, etc.), its designation as a target is considered incorrect for typical drug discovery contexts.

Other names

ethanedioateC₂O₄²⁻oxalate dianion

Not a direct drug target with mechanisms akin to inhibition or activation. Chelation (as with calcium—drugs or dietary measures that bind oxalate limit its absorption).