Oxalate production

Oxalate production" refers to the **metabolic process** by which the body synthesizes **oxalic acid (oxalate)**, primarily in the liver. The terminal steps involve conversion of glyoxylate to oxalate, catalyzed mainly by lactate dehydrogenase (LDH) rather than glycolate oxidase under physiological conditions. This process is modulated by factors such as NADH, lactate, alanine, and the overall metabolic state of hepatocytes. While not itself a molecular target like an enzyme or receptor, dysregulation of this pathway contributes to pathological conditions such as kidney stone formation and primary hyperoxaluria[1]. Thus, therapeutic strategies often focus on inhibiting enzymes involved in this pathway rather than targeting "oxalate production" per se.