Oxalobacter formigenes-derived factor receptor

The Oxalobacter formigenes-derived factor receptor is a putative cell-surface receptor located on the apical membrane of intestinal epithelial cells that mediates the action of secretagogues produced by the gut commensal bacterium Oxalobacter formigenes (Arvans et al., 2017). These secretagogues, recently identified as Sel1-like proteins and specific derived peptides known as P8 and P9, trigger a signaling cascade involving Protein Kinase A (PKA) upon binding to the receptor (Arvans et al., 2023). Activation of this pathway leads to the upregulation and increased apical membrane expression of the oxalate transporters SLC26A6 and SLC26A2 (Hassan, Grantome). This process enhances enteric oxalate secretion, which effectively reduces the systemic absorption of oxalate and its subsequent excretion in the urine. Consequently, this receptor is a significant therapeutic target for the treatment of hyperoxaluria and the prevention of calcium oxalate kidney stones. While the exact molecular identity of the receptor remains to be fully characterized, evidence suggests it may belong to the G protein-coupled receptor (GPCR) family and potentially involve adenosine receptor signaling pathways (Musch et al., 2023).

Other names

Oxalobacter formigenes secretagogue receptorSel1-like protein receptorP8/P9 peptide receptorPutative intestinal oxalate secretagogue receptor

Agonism of the receptor triggers a PKA-dependent signaling pathway that increases the apical membrane recruitment and transport activity of SLC26A6 and SLC26A2, thereby stimulating intestinal oxalate secretion.