Target intelligence / Profile preview

Oxalyl-CoA decarboxylase

Molecular classification: Enzyme

Overview

Oxalyl-CoA decarboxylase (OXC) is a thiamin diphosphate (TPP)-dependent enzyme that catalyzes the decarboxylation of oxalyl-CoA to form formyl-CoA and carbon dioxide. This enzyme plays a critical role in oxalate metabolism, particularly in bacteria like *Oxalobacter formigenes*, and has therapeutic potential for treating hyperoxaluric conditions.

Mechanism of action

Enzymatic degradation of oxalyl-CoA to formyl-CoA and carbon dioxide.

Biological functions

Oxalate degradationCarbon dioxide productionDetoxification

Disease associations

HyperoxaluriaUrolithiasis (Kidney Stones)

Safety considerations

Potential for off-target effects when using bacterial enzyme or live bacteria as therapy.Risk of formyl-CoA accumulation if enzyme activity is not tightly regulated.

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