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Oxidative Stress

Molecular classification: Condition/Process

Overview

Oxidative stress is a biological condition characterized by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify these reactive intermediates or repair the resulting cellular damage. This imbalance leads to damage of cellular components such as proteins, lipids, and DNA. It is implicated in several diseases including cancer, neurodegenerative diseases, cardiovascular disease, diabetes, and aging.

Mechanism of action

Enhancing endogenous antioxidants or supplementing with exogenous antioxidants; Reducing sources of excessive ROS production

Biological functions

Cellular DamageAltered Signaling

Disease associations

CancerNeurodegenerative diseaseCardiovascular diseaseDiabetesAging

Safety considerations

Some ROS play essential roles in cell signaling and immune defense; complete elimination may disrupt normal physiology.

Biomarkers

Malondialdehyde (MDA)8-Oxo-deoxyguanosine (8-OHdG)

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