Oxidative stress in skin cells

Oxidative stress in skin cells refers to the condition where the production of reactive oxygen species (ROS) from sources such as mitochondrial respiration, NADPH oxidase activity, and external stimuli (UV radiation, pollutants) exceeds the skin's antioxidant defenses. This leads to molecular damage, dysregulation of signaling pathways (including MAPK, NF-κB, PI3K/AKT, JAK/STAT, and others), cellular senescence, impaired extracellular matrix synthesis, inflammation, and progression of skin aging and diseases such as dermatitis, psoriasis, and cancers. While pharmacological and cosmetic approaches often target this process using antioxidants or pathway modulators, "oxidative stress in skin cells" is not a single molecular entity and is thus not classified as a canonical therapeutic target molecule or receptor.

Other names

Oxidative stress (general)ROS imbalanceskin oxidative injuryReactive oxygen species stress in skin

ROS scavenging (direct neutralization of ROS); Upregulation of endogenous antioxidant pathways (e.g., Nrf2 activation); Inhibition of ROS-generating enzymes (e.g., NADPH oxidases); Protection of macromolecules from oxidation; Suppression of pro-inflammatory pathways (e.g., NF-κB, AP-1)