Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Oxidative stress-induced growth inhibitor 1 (OSGIN1) is a p53-responsive oxidative stress response protein that regulates cell death, apoptosis, and autophagy[1][2][3][4][5]. OSGIN1 mediates cell fate in response to stress signals by promoting cytochrome c release from mitochondria, activating apoptosis, and modulating autophagy. It is notably expressed in ovary, kidney, and liver, and its expression is upregulated during oxidative stress, ER stress, and DNA damage[1][2][3][4]. OSGIN1 plays a dual role in human health: - In vascular tissues, it is implicated in protection against lipotoxicity and preservation of endothelial function, suggesting a protective role in cardiovascular disease and atherosclerosis[1]. - In the respiratory tract, upregulation of OSGIN1 under cigarette smoke or particulate matter promotes autophagy and pulmonary remodeling, linking it to chronic respiratory disease mechanisms[2]. - In oncology, OSGIN1 is a tumor suppressor whose loss correlates with uncontrolled cell growth, but its presence can also contribute to cancer cell apoptosis[2][3]. OSGIN1 does not directly contribute to ROS production but rather mediates downstream effects of oxidative stress[1][3]. It is considered a molecular mediator, not a traditional receptor or enzyme, but has clear roles in stress signaling and cell fate decisions. Currently, no direct drug modulators are in clinical use, but its function in cell death pathways and stress response makes it a compelling candidate for further therapeutic exploration[2][3].

Other names

OKL38BDGIBone marrow stromal cell-derived growth inhibitorhuOKL38Pregnancy-induced growth inhibitor OKL38ovary kidney and liver protein 38