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Oxidative Stress-Induced Neuronal Death

Molecular classification: Other

Overview

Oxidative stress-induced neuronal death refers to the process by which neurons die as a result of an imbalance between the production of reactive oxygen species (ROS) and the cell's antioxidant defenses. This imbalance leads to cellular damage and is a key mechanism underlying neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and motor neuron diseases. Neuronal death from oxidative stress can occur via apoptosis, necrosis, or aberrant cell cycle reentry.

Mechanism of action

Modulation of reactive oxygen species production and/or scavenging; enhancement of antioxidant defenses

Biological functions

Cell deathApoptosisRegulation of reactive oxygen speciesMitochondrial dysfunction

Disease associations

Neurodegenerative diseaseAlzheimer's diseaseParkinson's diseaseMotor Neuron Diseases

Safety considerations

Poor blood-brain barrier penetration of antioxidantsInsufficient potency of antioxidants against established pathologyPotential for off-target effects of ROS modulatorsComplexity of oxidative stress pathways requiring multi-targeted approaches

Interacting drugs

Antioxidants

3 more in the full profile.

Biomarkers

Markers of lipid peroxidationMarkers of protein oxidationMarkers of DNA/RNA oxidationLevels of ROSActivity of antioxidant enzymes (SOD, catalase, glutathione peroxidase)

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