Oxidative stress marker

“Oxidative stress marker” is not a specific molecule or receptor but rather refers collectively to various biochemical indicators used to assess the presence and extent of oxidative damage within biological systems. These markers reflect modifications caused by reactive oxygen species (ROS) or reactive nitrogen species (RNS) on DNA, proteins, lipids, or other cellular components. Common examples are modified nucleic acids like *8-hydroxydeoxyguanosine* for DNA damage; *malondialdehyde* and *F2-isoprostanes* for lipid peroxidation; and protein carbonyls for protein oxidation. Measurement typically involves indirect quantification since direct measurement of ROS/RNS is technically challenging due to their high reactivity and short lifespan. The clinical utility lies in evaluating disease risk/progression in conditions where oxidative imbalance plays a role—such as cancer, cardiovascular disease, neurodegeneration—and monitoring response to interventions targeting redox balance.[1][3][5] This entry should be replaced with specific molecular targets if available—for example “NADPH oxidase,” “Myeloperoxidase,” or “8-hydroxydeoxyguanosine”—as those are individual entities with defined roles in biology and pharmacology.[1]

Other names

Oxidative stress biomarkersMarkers of oxidative damageRedox biomarkers