Oxidative Stress Pathway in Renal Tissue

The oxidative stress pathway in renal tissue represents an imbalance between the production of reactive oxygen and nitrogen species (ROS/RNS) and the kidney's antioxidant defense mechanisms. This imbalance leads to cellular damage, inflammation, and fibrosis, contributing to the pathogenesis of various kidney diseases, including AKI and CKD. Key components include ROS/RNS generating enzymes like NOX4, antioxidant enzymes (SOD, catalase, glutathione peroxidases), transcription factors like Nrf2 and NF-κB, and the autophagy pathway. Targeting this pathway involves modulating ROS/RNS production, enhancing antioxidant defenses, and regulating inflammatory signaling.

Other names

Renal Oxidative StressOxidative Stress in KidneyROS/RNS Imbalance in Kidney

Modulation of ROS/RNS production, enhancement of antioxidant defenses, regulation of inflammatory signaling, modulation of autophagy