Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Oxidative stress signaling
- Molecular classification
- Signaling pathway/network, Transcription factors (e.g., NRF2, FoxO, p53), Kinases (e.g., MAPK: ERK, JNK, p38), Enzymes (e.g., SOD, GPX, CAT, PRX), Redox sensors (KEAP1, thioredoxin)
01
Overview
Oxidative stress signaling describes the cellular sensing and response network to increased reactive oxygen species, coordinating antioxidant defense, repair, apoptosis, and cell fate decisions via interconnected pathways such as MAPK, NRF2–KEAP1, FoxO, and p53. Dysfunctional or excessive signaling contributes to disease progression in cancer, neurodegeneration, cardiovascular and metabolic disorders. It is not a direct molecular target but comprises actionable nodes for therapeutic intervention.
- Other names
- oxidative stress pathwayredox signalingROS signaling
02
Mechanism of action
Drugs typically act by: Activating antioxidant pathways (NRF2 signaling); Modulating kinase pathways (MAPK signaling: inhibiting ERK, activating p38 or JNK); Scavenging or reducing ROS (antioxidants); Regulating mitochondrial ROS production.
03
Biological functions
Regulation of antioxidant defensesSignal transductionApoptosisCell survivalCell proliferationImmune responseMitochondrial function and energy metabolismStress adaptation
04
Disease associations
CancerCardiovascular diseaseNeurodegenerative diseaseInflammationDiabetes and metabolic disordersAging
05
Safety considerations
Redox imbalance (pro-oxidant or overactive antioxidant effects)Off-target effects due to broad pathway involvementPotential for impaired cell signaling or apoptosis (with indiscriminate ROS suppression)
06
Interacting drugs
NRF2 activators (e.g., bardoxolone)
3 more in the full profile.
07
Biomarkers
Superoxide dismutase (SOD) activityMyeloperoxidase (MPO) activityGlutathione (GSH) levels3-chlorotyrosine (3-Cl-Tyr)Malondialdehyde (MDA) (indicative of lipid peroxidation)
Beyond the preview
Go deeper on Oxidative stress signaling.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Oxidative stress signaling.