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Target intelligence / Profile preview
Oxidized Low-Density Lipoprotein (Ox-LDL)
- Target
- Ox-LDL
- Molecular classification
- Lipoprotein, Modified protein
01
Overview
Oxidized low-density lipoprotein (Ox-LDL) refers to LDL particles that have undergone oxidative modification, primarily through the action of free radicals. This process alters both the lipid and protein components of LDL, resulting in a particle with pro-atherogenic properties. Ox-LDL is strongly associated with the development and progression of atherosclerosis, contributing to plaque formation in arterial walls by promoting inflammation, endothelial dysfunction, and foam cell formation.
02
Mechanism of action
N/A
03
Biological functions
Lipid transportInflammationEndothelial dysfunctionFoam cell formationAtherogenesis
04
Disease associations
AtherosclerosisCardiovascular disease
05
Safety considerations
Contribution to plaque formation
06
Biomarkers
Elevated levels of oxLDL
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