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Target intelligence / Profile preview
Oxidized Low-Density Lipoprotein Formation (OxLDL Formation)
- Target
- OxLDL Formation
- Molecular classification
- Lipoprotein modification, Oxidation product
01
Overview
Oxidized low-density lipoprotein (OxLDL) formation refers to the oxidative modification of native LDL particles, a process that occurs primarily under conditions of oxidative stress. This involves both lipid peroxidation and protein oxidation within the LDL particle, resulting in complex products with altered biological properties. OxLDL plays a central role in the development of atherosclerosis by promoting foam cell formation, endothelial dysfunction, and inflammation.
- Other names
- OxLDLOxidized LDLLDL Oxidation
02
Mechanism of action
N/A
03
Biological functions
Immune activationInflammationMacrophage activationEndothelial dysfunction
04
Disease associations
AtherosclerosisCardiovascular diseaseCoronary artery diseaseInflammation
05
Safety considerations
Elevated levels associated with increased cardiovascular risk
06
Biomarkers
OxLDL levels in plasma
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