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Target intelligence / Profile preview
Oxidored-nitro domain-containing protein 1 (NOR1)
- Target
- NOR1
- Molecular classification
- Enzyme (nitroreductase-like activity), Other (putative tumor suppressor)
01
Overview
Oxidored-nitro domain-containing protein 1 (NOR1), also known as OSCP1, is a protein that acts as a tumor suppressor. It is involved in various cellular processes, including cell cycle regulation, apoptosis, and metabolic reprogramming. NOR1 is downregulated in several types of cancer, including nasopharyngeal carcinoma and leukemia, often due to promoter hypermethylation. Its re-expression can inhibit cancer cell growth by disturbing energy metabolism and promoting apoptosis. NOR1 also suppresses the epithelial-mesenchymal transition (EMT) process, which is crucial for cancer cell invasion and metastasis. This molecule does not fit into traditional categories like receptors or ion channels, but it plays a significant role in cancer biology, making it a potential therapeutic target.
- Other names
- OSCP1human solute carrier protein 1 (hOSCP1)
02
Mechanism of action
Inhibition of glycolysis and mitochondrial respiration, induction of apoptosis through mitochondrial pathway, suppression of epithelial-mesenchymal transition (EMT)
03
Biological functions
Signal transductionCell cycleApoptosisCell proliferationCell death
04
Disease associations
Cancer (nasopharyngeal carcinoma, leukemia, etc.)
05
Safety considerations
Not specifically documented, but as a potential therapeutic target, its manipulation could have unforeseen effects on cellular metabolism
06
Interacting drugs
CB1954 (activated by NOR1)
07
Biomarkers
Potential biomarker for cancer diagnosis and prognosis due to its epigenetic silencing in various cancers
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