Oxidoreductase acting on CH-NH group donor

Oxidoreductases acting on CH-NH group donors are enzymes classified under EC 1.5 in the Enzyme Commission numbering system[1][3][5]. They catalyze oxidation-reduction (redox) reactions in which a substrate containing a CH-NH group (such as a secondary amine) acts as a hydrogen or electron donor and generates a C=N double bond as the primary product[6][8]. This class is diverse, covering dehydrogenases that act on various substrates and use different physiological acceptors including NAD(+), NADP(+), oxygen, disulfides, flavins, quinones, or iron-sulfur proteins[2][5]. EC 1.5 oxidoreductases play important roles in intermediary metabolism, amino acid catabolism, product detoxification, cell signaling, and neurotransmitter regulation. Individual enzymes in this class (such as monoamine oxidase or sarcosine dehydrogenase) are drug targets and studied for their role in diseases, but the EC 1.5 group itself refers to a mechanistic class rather than a single molecular entity[1][3][6].

Other names

EC 1.5 oxidoreductaseEC 1.5 enzymeDehydrogenase acting on CH-NH group donorAmino group oxidoreductase

Inhibition or modulation of redox enzymatic activity; Alteration of substrate dehydrogenation