Target intelligence / Profile preview

Oxidoreductase NAD-binding domain-containing protein 1 (OXNAD1)

Target
OXNAD1
Molecular classification
Enzyme (oxidoreductase family), NAD-binding domain-containing protein, Other (mitochondrial protein)
01

Overview

OXNAD1 encodes a mitochondrial protein with a predicted NAD-binding oxidoreductase domain, implicated broadly in cellular redox reactions and metabolism. While its specific physiological function in humans is not well defined, it is classified bioinformatically as an oxidoreductase based on conserved catalytic domain architecture. The protein is likely involved in metabolite interconversion and redox balance in mitochondria but lacks detailed functional annotation from direct experimental studies. There are nominal disease associations (phototoxic dermatitis, basal cell nevus syndrome 1) derived from gene-disease association databases, but no clear mechanistic or therapeutic links have been established. OXNAD1 is not an established drug target, and there is no evidence to support its use as a biomarker or as a source of safety concerns in therapeutic settings.

Other names
OXNAD1MGC15763RFTN1-AS1Oxidoreductase NAD-binding domain-containing protein 1RFTN1 antisense RNA 1
02

Mechanism of action

Not applicable; OXNAD1 is not a confirmed drug target

03

Biological functions

Redox reactions (metabolite interconversion)Putative involvement in mitochondrial oxidative metabolism (based on subcellular localization, not direct experimental evidence)Potential regulation by transcription factors and microRNAs (bioinformatics prediction)
04

Disease associations

Associated: Phototoxic dermatitisAssociated: Basal cell nevus syndrome 1Other: Putative roles in cancer based on gene perturbation datasets, but not established as causal
05

Safety considerations

Not applicable, since OXNAD1 is not a direct therapeutic target
06

Interacting drugs

None known or confirmed. No approved drugs directly target OXNAD1 as of this review.
07

Biomarkers

None established for patient selection or efficacy monitoring

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