Oxygen delivery to wound site

Enhancement of **oxygen delivery to wound sites** is a therapeutic principle, not a single molecular target, used to promote wound healing, especially in chronic or hypoxic wounds. Oxygen is critical for cellular respiration, energy production, angiogenesis, bacterial defense, and cell proliferation necessary for all stages of wound repair. Strategies to increase wound oxygenation include systemic (e.g., hyperbaric oxygen therapy), topical (e.g., local oxygen-delivery systems, oxygen-emitting dressings), and material-based approaches (e.g., enzyme or peroxide-loaded hydrogels), all aiming to overcome hypoxia and restore normal healing. These interventions are particularly effective in diabetic ulcers, compromised wounds, and ischemic tissues. However, oxygen delivery is a multidimensional approach involving numerous molecular mediators rather than being a molecular target itself[1][2][3][4][5].

Other names

oxygenation of woundwound oxygen deliverywound oxygenationenhancing tissue oxygenwound site oxygenation

Increase in local oxygen partial pressure - Enhancement of angiogenesis - Support of fibroblast and epithelial cell function - Augmentation of reactive oxygen species (ROS)–mediated bacterial killing by neutrophils - Modulation of immune and inflammatory responses - Facilitation of collagen synthesis and tissue remodeling[3][1][2][4]