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The term "oxygen-free radical scavenging activity" describes the capability of molecules—primarily antioxidants—to neutralize reactive oxygen species (ROS) such as superoxide (O₂•−), hydroxyl radicals (•OH), and hydrogen peroxide (H₂O₂) by donating electrons or hydrogen atoms, chelating redox-active metals, or catalyzing their conversion into harmless substances. This activity is crucial for protecting cells against oxidative stress, which is implicated in cellular damage and the pathogenesis of numerous diseases, including cancer, neurodegeneration, and cardiovascular disorders. Measurement of this activity is widely used to evaluate the therapeutic potential of antioxidants, but the term itself does not refer to a distinct molecular entity or therapeutic target.
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