Oxyntomodulin receptor

Oxyntomodulin does not have a unique, dedicated receptor. Instead, it acts as a dual agonist at the Glucagon-like peptide-1 receptor (GLP1R) and the Glucagon receptor (GCGR). It binds and activates both these receptors, mediating its physiological effects through them, which include appetite suppression, increased energy expenditure, and improved glucose tolerance. Dual agonists targeting both receptors are being investigated as treatments for obesity and type 2 diabetes mellitus.

Other names

OXM receptorOxyntomodulin receptorsGLP1R/GCGR (Oxyntomodulin)

Dual agonism of GLP-1 receptor and glucagon receptor leading to increased cAMP production, PKA activation, and downstream signaling cascades. Biased agonism may also play a role, preferentially activating certain signaling pathways.