Oxysterol-binding protein 1 (OSBP)

Oxysterol-binding protein 1 (OSBP) is a cytosolic lipid-transfer protein that acts as a key mediator of non-vesicular lipid transport, primarily moving cholesterol and oxysterols between the endoplasmic reticulum and Golgi membranes[9][3][6]. OSBP contains a central oxysterol-binding protein-related domain (ORD), which harbors a hydrophobic cavity suited for binding oxysterols, cholesterol, and specific phospholipids, as well as the ability to bind certain phosphoinositides[3][1]. OSBP regulates cellular sterol and sphingolipid metabolism, impacting membrane composition and signaling at membrane contact sites[6][9]. Dysregulation of OSBP function is linked to diseases such as cancer and cardiovascular disease, though OSBP itself is not a classical receptor but rather functions as a key lipid transporter and sensor[4][7]. Experimental OSBP inhibitors, while promising as research tools and in early-stage drug discovery, present challenges due to their potential to disrupt fundamental lipid regulatory networks essential for cellular physiology.

Other names

Oxysterol binding proteinOSBPOSBP1oxysterol-binding protein 1

Inhibitors of OSBP block non-vesicular lipid/sterol trafficking between endoplasmic reticulum (ER) and Golgi, disrupting lipid homeostasis, leading to altered signaling and cellular function[8].