Oxysterol-binding protein-like 3 (OSBPL3)

Oxysterol-binding protein-like 3 (OSBPL3) is a member of the oxysterol-binding protein family that functions as an intracellular lipid receptor and lipid transfer protein[1][3][7]. OSBPL3 contains an N-terminal pleckstrin homology (PH) domain and a highly conserved C-terminal OSBP-like sterol-binding domain, enabling it to bind specific phosphoinositides and participate in non-vesicular lipid exchange at membrane contact sites such as between the endoplasmic reticulum and plasma membrane[2][3][5][6]. This protein plays critical roles in regulating cell adhesion, cytoskeleton organization, vesicle trafficking, and cellular lipid metabolism[1][3][7]. Aberrant expression or mutation of OSBPL3 is implicated in diverse human cancers and is associated with tumor growth, metastasis, prognosis, and immune microenvironment modulation[1][3]. OSBPL3 is broadly expressed across human tissues, with the highest physiological expression in the parathyroid gland[1]. No approved drugs specifically target OSBPL3, but it is considered a potential therapeutic and prognostic target in oncology and metabolic diseases[1][3][7].

Other names

Oxysterol-binding protein-related protein 3ORP3KIAA0704OSBP3ORP-3OSBP-related protein 3