Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Oxysterol-binding protein-related protein 5 (OSBPL5)
- Target
- OSBPL5
- Molecular classification
- Intracellular lipid receptor, Lipid transporter, Oxysterol-binding protein family, Pleckstrin homology domain-containing protein
01
Overview
Oxysterol-binding protein-related protein 5 (OSBPL5) is a member of the oxysterol-binding protein family, functioning primarily as a lipid transporter at membrane contact sites. It mediates counterexchange of phosphatidylinositol 4-phosphate and phosphatidylserine between the endoplasmic reticulum and the plasma membrane, contributing to cholesterol trafficking in concert with NPC1. OSBPL5 also modulates cell signaling pathways such as mTORC1, influencing cell proliferation and migration, and its dysregulation is linked to cancer metastasis and poor prognosis.
- Other names
- OBPH1ORP5oxysterol binding protein like 5oxysterol binding protein homologue 1KIAA1534
02
Mechanism of action
Drugs targeting OSBPL5 might affect lipid transfer and membrane homeostasis, mTOR signaling, and ER-mitochondria communication, but no approved drugs are known to target OSBPL5 directly.
03
Biological functions
Non-vesicular lipid transport at membrane contact sitesPhosphatidylserine and phosphatidylinositol 4-phosphate exchange between the endoplasmic reticulum and plasma membraneCholesterol trafficking, especially involving endosomes/lysosomesRegulation of mTORC1 signalingModulation of cell proliferation, migration, and invasionMaintenance of membrane lipid composition and homeostasis
04
Disease associations
Cancer (notably pancreatic, lung, and cervical, associated with metastasis and poor prognosis)Lenz-Majewski hyperostotic dwarfismPeeling skin syndrome
Beyond the preview
Go deeper on Oxysterol-binding protein-related protein 5 (OSBPL5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Oxysterol-binding protein-related protein 5 (OSBPL5).