Oxysterol-binding protein-related protein 7 (OSBPL7)

Oxysterol-binding protein-related protein 7 (OSBPL7) is a member of the oxysterol-binding protein (OSBP) family, which comprises intracellular lipid receptors involved in sterol binding and lipid transport. OSBPL7 possesses a conserved C-terminal OSBP-like sterol-binding (OHD) domain and an N-terminal pleckstrin homology (PH) domain, facilitating interaction with membranes and organelles. The protein plays a role in cholesterol and oxysterol sensing, cellular lipid trafficking, and may participate in the proteasomal degradation of Golgi SNARE proteins via interactions influenced by oxysterol levels[1][2]. It is primarily expressed in the gastrointestinal tract and is implicated in cellular lipid homeostasis. OSBPL7 has emerging roles as a potential therapeutic target, with at least one small-molecule inhibitor (OSBPL7-IN-1) reported; such inhibition may modulate cholesterol efflux and protein turnover in cells[4]. Diseases associated with OSBPL7 include opisthorchiasis and adult medulloblastoma, while the broader OSBP/ORP family plays essential roles in lipid balance and may contribute to cancer and infection susceptibility[1][2].

Other names

Oxysterol-binding protein like 7ORP7OSBP-related protein 7MGC71150oxysterol-binding protein-related protein 7ORP-7

Inhibition of oxysterol binding and function (for OSBPL7-IN-1), Increase in ABCA1 at the plasma membrane (linked to cholesterol efflux), Modulation of proteasomal degradation of Golgi SNARE proteins