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Target intelligence / Profile preview
Oxytocin Receptor (OXTR)
- Target
- OXTR
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Receptor
01
Overview
The oxytocin receptor (OXTR) is a G-protein-coupled receptor that binds oxytocin and mediates its effects on uterine contraction, milk ejection, social behavior, and other physiological processes. It is expressed in various tissues, including the uterus, mammary glands, and brain, and plays a crucial role in reproduction, social bonding, and emotional regulation. OXTR is a therapeutic target for psychiatric disorders and vascular dysfunction.
02
Mechanism of action
Agonist of OXTR leading to Gq/11 protein activation and downstream signaling cascades.
03
Biological functions
Signal transductionUterine contractionMilk ejectionSocial bondingEmotional regulationVascular functionCell differentiationCell migrationCell proliferationStress responseInflammation
04
Disease associations
Psychiatric disordersAutism spectrum disordersPostnatal depressionSocial anxietyVascular dysfunction
05
Safety considerations
Potential for off-target effects due to vasopressin binding.Careful consideration of dosage and administration route to minimize adverse effects.
06
Interacting drugs
Oxytocin
1 more in the full profile.
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