Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
P-glycoprotein 1 (P-gp)
- Target
- P-gp
- Molecular classification
- ATP-binding cassette (ABC) transporter superfamily, MDR/TAP subfamily, Transporter
01
Overview
P-glycoprotein 1 (P-gp) is an evolutionarily conserved transmembrane protein crucial for cellular defense against toxins but also responsible for clinically significant multidrug resistance due to its broad substrate specificity as an active efflux pump powered by ATP hydrolysis. It impacts both normal physiology—by protecting sensitive tissues—and pharmacology—by influencing how drugs are absorbed/distributed/metabolized/excreted/resisted throughout the body.
- Other names
- MDR1ABCB1CD243Multidrug resistance protein 1ATP-binding cassette sub-family B member 1Cluster of differentiation 243Permeability glycoprotein
02
Mechanism of action
ATP-dependent efflux; actively pumps substrates out of cells against concentration gradients.
03
Biological functions
Efflux pumpXenobiotic transportDrug transportCytokine secretionLymphocyte survivalAntigen presentationADMET regulation
04
Disease associations
Cancer (multidrug resistance)Drug-drug interactionsAltered drug bioavailability
05
Safety considerations
Multidrug resistance in cancerDrug-drug interactions due to altered pharmacokineticsVariations in drug bioavailabilityPotential for food-drug interactions
06
Interacting drugs
Many drugs are P-gp substrates or inhibitors
1 more in the full profile.
Beyond the preview
Go deeper on P-glycoprotein 1 (P-gp).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on P-glycoprotein 1 (P-gp).