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Target intelligence / Profile preview
P-selectin glycoprotein ligand-1 (PSGL-1)
- Target
- PSGL-1
- Molecular classification
- Type I transmembrane glycoprotein, Mucin-like glycoprotein, Receptor
01
Overview
P-selectin glycoprotein ligand-1 (PSGL-1), also known as CD162 and encoded by the SELPLG gene, is a type I transmembrane mucin-like glycoprotein primarily expressed on most hematopoietic cells. It mediates leukocyte rolling and extravasation, and functions as a negative immune checkpoint receptor modulating T-cell activation and exhaustion. It interacts with P-, E-, and L-selectins, as well as VISTA, Siglec-5, versican and CCL19/CCL21, playing a role in inflammation, cancer, and HIV infection.
- Other names
- CD162Selectin P ligandSELPLG
02
Mechanism of action
Pan-selectin antagonism (soluble recombinant PSGL-1); Blocks leukocyte influx; Reduces T-cell exhaustion.
03
Biological functions
Cell adhesionLeukocyte traffickingImmune regulationT-cell migrationNegative immune checkpoint regulation
04
Disease associations
Inflammatory diseasesCancerHIV infectionOrgan transplant rejectionAcute respiratory distress syndrome (ARDS)
05
Safety considerations
Potential for broad immunosuppression when targeting PSGL-1T-cell exhaustion
06
Interacting drugs
Soluble recombinant forms of human PSGL-1
3 more in the full profile.
07
Biomarkers
PSGL-1 expression level (HIV disease progression)sLe^x^ on PSGL-1
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