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Target intelligence / Profile preview
P-type Calcium Channel (None)
- Target
- None
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
P-type calcium channels are voltage-gated calcium channels (VGCCs) primarily located in neurons within the central and peripheral nervous systems. They mediate calcium influx upon membrane depolarization, which is essential for neurotransmitter and hormone release at synaptic terminals. Mutations in the gene encoding the P-type calcium channel α1 subunit (CACNA1A) are linked to several neurological disorders. P-type channels are selectively blocked by ω-agatoxin IVA.
- Other names
- CaV2.1CACNA1ACACNL1A4SCA6MHP1MHP
02
Mechanism of action
ω-agatoxin IVA selectively blocks P-type calcium channels, preventing calcium influx and subsequent neurotransmitter/hormone release.
03
Biological functions
Calcium ion transmembrane transportNeurotransmitter releaseHormone releaseRegulation of neuronal excitabilitySynaptic transmission
04
Disease associations
Episodic ataxia type 2Familial hemiplegic migraine type 1Spinocerebellar ataxia type 6Neurological disorders
05
Safety considerations
Non-selective calcium channel blockers can have broad effects due to the widespread distribution of calcium channels.Inhibition of P-type calcium channels may disrupt normal neuronal function and synaptic transmission.
06
Interacting drugs
ω-agatoxin IVA
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