Target intelligence / Profile preview

P-type cation-transporter ATPase 4 (PfATP4)

Target: PfATP4
Molecular classification: P-type ATPase, Transporter, Enzyme

Overview

PfATP4 is a P-type cation-transporter ATPase found in *Plasmodium falciparum*. It functions as a Na⁺ efflux pump, actively extruding Na⁺ from the cytosol of intraerythrocytic parasites to maintain low intracellular sodium concentrations. It is an essential membrane protein and a validated antimalarial drug target.

Mechanism of action

Inhibition of PfATP4 activity, leading to intracellular Na+ accumulation and parasite death

Biological functions

Sodium transportIon homeostasispH regulation

Disease associations

Infection

Safety considerations

Potential for resistance developmentOff-target effects in lower eukaryotes (protozoa, fungi, bryophytes)

Interacting drugs

Spiroindolones

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