p14ARF tumor suppressor protein (p14ARF)

The queried term "Tumor antigens associated with p14ARF-expressing cells" does not refer to a specific molecule or receptor but describes antigens linked to cells expressing the p14ARF tumor suppressor protein, encoded by the CDKN2A locus in an alternate reading frame from p16INK4a[1][2][4]. p14ARF acts as a tumor suppressor through p53-dependent and p53-independent mechanisms, including binding MDM2 to stabilize p53, antagonizing Myc and E2F1 transcription, inhibiting ribosome biogenesis via NPM interaction, and promoting apoptosis upon stress-induced relocalization from the nucleolus[1][2][3][4]. It undergoes post-translational modifications like PRMT1-mediated arginine methylation (at R87/88/96/99 in its NLS/NoLS) for redistribution and apoptosis, and ubiquitination by CRL2^Prame E3 ligase (involving RBX1, Cullin2, EloB/C, Prame) for degradation in cancer cells[1][2]. The term is imprecise for a therapeutic target like a receptor or enzyme, as p14ARF itself is the protein, not antigens on its expressing cells[1][2][4][7].

Other names

p14 ARFARFtumor suppressor p14/ARFp14arf