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Target intelligence / Profile preview
p21 (RAC1) Activated Kinase 1 (PAK1)
- Target
- PAK1
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
PAK1 is a serine/threonine protein kinase and a member of the p21-activated kinases (PAKs), which are critical effectors linking Rho family GTPases—specifically Cdc42 and Rac—to cytoskeletal reorganization and nuclear signaling. It plays essential roles in regulating cell motility, morphology, gene expression, cell cycle progression, survival, angiogenesis, DNA repair, hormone sensitivity, and metabolism. Mutations or dysregulation of PAK1 have been linked with several diseases, including intellectual developmental disorder, breast cancer, and acute myeloid leukemia. It is also implicated in oncogenesis generally, viral pathogenesis, cardiovascular dysfunctions, and neurological disorders.
02
Mechanism of action
Kinase inhibition; induction of differentiation/apoptosis
03
Biological functions
Signal transductionCytoskeleton remodelingCell motilityCell growthCell cycle progressionAngiogenesisSurvivalApoptosisMetabolic regulationRegulation of insulin secretionRedox balance
04
Disease associations
CancerIntellectual developmental disorderAcute myeloid leukemiaMyelodysplastic syndromesAutism spectrum disordersCardiovascular dysfunctionsNeurological disordersViral pathogenesis
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