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Target intelligence / Profile preview
P21-activated kinase 4 (PAK4)
- Target
- PAK4
- Molecular classification
- Serine/threonine kinase, Enzyme, p21-activated kinase (PAK), Group II PAK
01
Overview
P21-activated kinase 4 (PAK4) is a serine/threonine protein kinase and a member of the p21-activated kinases (PAKs), specifically classified as a Group II PAK. It plays critical roles in various cellular signaling pathways, particularly those regulating cytoskeletal dynamics, cell migration, proliferation, survival, and oncogenic transformation. Overexpression or dysregulation of PAK4 has been implicated in several cancers, making it an attractive therapeutic target. Inhibitors targeting its kinase activity are under investigation for anti-cancer therapy potential.
02
Mechanism of action
Kinase inhibition
03
Biological functions
Actin cytoskeleton reorganizationCell motilityCell proliferationCell survivalCell cycle progressionMitosisEmbryonic developmentSignal transduction
04
Disease associations
CancerOncogenic transformation
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesToxicity related to disruption of normal cellular functions (e.g., cell cycle, cytoskeletal dynamics)
06
Interacting drugs
KY‑04045
2 more in the full profile.
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