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Target intelligence / Profile preview
P2X Purinergic Receptor (P2XR)
- Target
- P2XR
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The P2X purinergic receptor family comprises trimeric ligand-gated ion channels activated exclusively by extracellular ATP, mediating fast excitatory responses across many tissues. Their broad distribution underlies their involvement in neurotransmission, nociception/pain pathways—including neuropathic/inflammatory conditions—immune responses via inflammasome activation (notably through subtype-specific effects like those mediated by P2RX7), vascular tone regulation, platelet function modulation—and they represent promising therapeutic targets for several major disease areas due to their unique pharmacology and pathophysiological roles.
- Other names
- P2X receptorATP-gated ion channel
02
Mechanism of action
Antagonism of P2X receptor subtypes, Allosteric modulation
03
Biological functions
Synaptic transmissionNociceptionInflammation regulationApoptosisSmooth muscle contractionPlatelet aggregationImmune response
04
Disease associations
Chronic inflammationNeuropathic painInflammatory painCancer progressionNeurodegenerative disordersCardiovascular diseaseEndocrine dysfunctions
05
Safety considerations
Potential for off-target effects due to widespread expressionSubtype selectivity challenges
06
Interacting drugs
A317491
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