Target intelligence / Profile preview

P2X purinoceptor 1

Molecular classification: Receptor, Ion channel, Ligand-gated ion channel

Overview

P2X purinoceptor 1 is a ligand-gated ion channel activated by extracellular ATP. It functions as a cation-permeable channel with relatively high calcium permeability and is primarily expressed in smooth muscle and platelets. This receptor plays a key role in sympathetic vasoconstriction, male reproductive function, and possibly platelet aggregation, and has been implicated in leukemogenesis.

Other names: ATP receptorPurinergic receptor P2X₁

Mechanism of action

ATP binding and channel opening; to be filled in if targeting drug is known.

Biological functions

Synaptic transmissionVasoconstrictionPlatelet aggregationCation transportCalcium signaling

Disease associations

Cardiovascular diseaseMale infertilityLeukemogenesis

Safety considerations

Development of selective antagonists needed for therapeutic applications.Potential impact on blood pressure regulation.

Beyond the preview

Go deeper on P2X purinoceptor 1.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on P2X purinoceptor 1.

Explore the full profile